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The House-Cuddy stuff was fair enough. And for my money they should have left it there. The breakup was a little bit much imo, and the end of 7 was just stupid. If they had ended it at the end of 7, with House sitting on a beach it would have been okay. Stupid he can do something without punishment but fair enough I guess.

Season 8 was stupid. For one, Foreman would not have been made the Dean of Medicine. It makes very little sense, especially given he has no training in admin stuff, wasn't a previous Department Head (well, briefly he was) and was clearly just a case of needing someone to fill in for Lisa Edelstein as they now had no Cuddy character. Wilson wouldn't work for that role. I'd even have rather they got Cameron back for it than have Foreman. I get after 7 seasons you don't want an entirely new character as that wouldn't work with House needing to do insane stuff all the time anyway.

Season 8 does have an excellent episode with Wilson and House giving chemo to Wilson in House's apartment. It's quite touching really.

The end of the whole thing was just ridiculous. Sure, it shows House cares about Wilson but he's basically cocked everything up and it just felt wrong.

The best end points for me, would have been the end of the two parter opener to 6 (addicts shouldn't go back to places they used to be means House doesn't want to return at that point anyway). Have him get together with Cuddy at the end of 6 and end it there. The end of 7 might have worked but was still a bit silly imo. They pushed it to far, and I can understand why you'd want to ride it out as much as possible. But I wish they had ended it with a different outcome for all involved.

They've made Samwell Tarly more useless.
In the book, he sends ravens off to at least Castle Black and the Shadow Tower, setting up for Stannis Baratheon to flank Mance Rayder via the Bay of Seals. He also kills a Wight using the dragonglass dagger Lord Snow gives him.
In the show, apparently he didn't send those ravens off, and the Wight was killed by Jeor Mormont with fire arrows.

Artisan Whitebeard doesn't exist in the show. The whole point of him in A Storm of Swords is to inform Dany Stormborn that Jorah sold her out to save himself after Jorah calls him out for concealing his true identity (and link back to the three betrayals prophecy Mirri gives her in A Game of Thrones)

There isn't a believable way for Bran, Hodor, Osha and Rickon to stumble upon the Crannogmen and still end up at the Wall together (and meet Sam and Gilly), with the Neck being south of Winterfell.

Lord Snow realises he wants to touch Ygritte's naughty places causing a conflict between his love for her, and his duty to The Watch. Also, could be hinting at Dany's sack of Astapor, given that she has dragons who breathe fire

The Red Wedding, Sansa's marriage, Rhllor bringing back Beric Dondarrion (and his subsequent death). They've also named the finale for the Valyrian word for mother, which hints at Cat's resurrection, but could also feature the Mother of Dragons (in Mereen), or Lady Olenna Redwyne and Cersei.